No estás segur
a.
Both are questions. Here are some examples of how I understand their usage.
¿Qué tiene?
= What do you have (illness)?
= What have you got?
= What's wrong (with you)?
¿Qué tiene?
= What is it that you've done?
= What's up? (questioning what you've done)
¿Qué te pasa?
= What's wrong?
= What's the matter?
¿Qué pasa?
= What's up?
= What's happening?
= How's it going?