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I believe these are other ways to use el colmo, in its negative sense (meaning the last straw):
I am at my wit's end.
I am at/on the brink (here, of a nervous breakdown, of quitting my job, etc.).
That was my last nerve. (You're on my last nerve.)
That was the straw that broke the camel's back. (Es la gota que colma el vaso.)
That took me over the edge.
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