Settle in, as in new surroundings, is "instalarse" and eventually "familiarizarse".
I'm not sure about "settle in" in the context of you (old) home. For the meaning I grasp from your sentence I would say "te llamaré cuando ya esté en casa tranquilo" meaning, once I get home, feed the cat, take the garbage out, pour me a glass of white wine and be wearing slippers.
__________________
[gone]
|