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You're right, irse is the verb being used, and it can be translated as 'to leave'.
Pronouns go before the conjugated verb in a specific order. The reflexive pronoun is the left-most pronoun. Object pronouns are placed closer to the verb.
The direct object pronoun, if any, is closest to the verb.
The indirect object pronoun, if any, is to the left of the direct object pronoun.
In Spanish, it's very common to get 'impersonal' about things. You don't drop something; it drops from you. This same kind of idea is in play here. The person is not losing her voice; it is leaving her.
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