Specific examples and questions from where you found these words and the usage that has caused you trouble would be very helpful.
Replies from what you have just said may be awfully confusing.
However:
1) There is no neuter gender in Spanish. When there is a notion of neuter gender, is usually expressed in masculine.
Context will tell the difference between "niño"-child and "niño"-boy.
2) Without knowing what exactly caused you confusion:
Your question could be related to the fact that the verb to be corresponds to two different verbs in Spanish: "ser" and "estar".
Or it could be related to the fact that the pronoun "you" corresponds to "tú" in singular informal, "usted" singular formal, "ustedes" plural informal/formal and "vosotros" informal.
So, "you are" and "you're" may be:
tú eres/estás
usted es/está
ustedes son/están
vosotros sois/estáis