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Don't take it personal, Malila, because the expression is as impersonal as they come. "Thanks, man" is used without any regard to the gender of the listener.
I would seldom use the phrase when addressing a female. Instead, I would just omit the filler on the end. "Thanks, ma'am" sounds a bit too formal in my neck of the woods, but it is very much heard in the South (Southern United States).
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