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despedirse de alguien = say goodbye to someone
despedir a alguien = fire someone
Me despido de Juan. = I'm saying goodbye to John.
Despido a Juan. = I'm firing John.
Your sentences appear in second person command form (suffixed as is, with the pronoun me, an accent mark is required to retain proper stress). With the suffix me, the speaker is asking another person to do the firing or saying goodbye for him (on his behalf).
Despídeme a Juan. = Fire John (for me, on my behalf).
Despídeme de Juan. = Say goodbye to John for me (on my behalf).
A more polite form may be constructed with the conjunction 'que', followed by a verb in the present subjunctive.
Que me despide de Juan. = Please say goodbye to John for me.
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