¡Qué vaina!

[poli]

It means, how annoying! in part Colombia, but I would like to know if it is used elsewhere.

[Rusty]

This is used in Central America and in Mexico.
It can be translated using stronger language (cursing).
The word itself can also be injected into a phrase as a filler.

[AngelicaDeAlquezar]

I've never heard it in Mexico where I live, but it might be used in some other regions; probably the South-East, which has a lot in common with Central American countries. :D

[wrholt]

My first-year roommate at university (mid-late 1970s), who was from Venezuela, often used this expression. He also used "esa/esta vaina" to mean "this/that stuff/thing".

[poli]

I have heard vainoso too. As an adjective to mean annoying (I think) or a noun to mean thing.

[pinosilano]

Mi contributo:
https://www.speakinglatino.com/dominican-spanish-word-vaina/
:p