Send my regards

Send my regards
 

It occurred to me today that I don't know a good way of saying this polite
conversational devise in Spanish. Do you say Das mis recuerdos a tu esposa?
It doesn't sound right, but I think I heard something similar to it.
Thanks.

Da mis recuerdos a tu esposa is correct, but it's probably a bit more common to omit the determiner mis. You can also just say recuerdos a tu esposa.
If you want, you can substitute saludos for recuerdos, or you can say Saludo a tu esposa.

I'd say:

Send my regards to your wife.
Me salada a su esposa por favor.
Mando saludos a su esposa.
Salude a su esposa de mi parte.

(Those are in Usted, it works just fine using Tú as well)

Me saladas a tu esposa por favor.
Mando saludos a tu esposa.
Saluda a tu esposa de mi parte.

Thanks Rusty and David for your help. I missed the occasion to use it today, but will be able to the next time the situation arises.

Store away handy phrases to use when the situation arises. That's what I always did. :)

my 2 cents
"dale recuerdos de mi parte a tu mujer"
"dale recuerdos de mi parte a tu esposa"

Saludos :D